Neurological disease is a common problem encountered in equine practice and the ability to perform a neurological examination is an essential skill that all veterinarians involved in equine practice should learn. The aim of this lecture is to provide delegates with the ‘practical know-how’ to determine if a neurological abnormality exists and the knowledge and confidence to interpret their findings in order to localise the lesion to a specific anatomic region of the nervous system. Videos will be used to demonstrate the various neurological syndromes that may be encountered in practice; and practitioners will have an opportunity to practice localising the lesion on a wide variety of different cases.