This presentation will begin with a brief overview of the century’s long history and use of cold therapy for treatment of diseases and tumors. We'll then discuss the principles of minimally-invasive cryoablation, the mechanism of ice formation within tissues, and its modern veterinary applications, especially highlighting its dermal and subcutaneous use for tumor ablation. Several histological diagnoses and anatomical locations will be reviewed with case reports of several patients. We will discuss how carbon-dioxide powered cryoablation can be integrated into a comprehensive cancer treatment plan. Finally, we’ll explore cryoablation’s potential to trigger the immune system.